Can I install a 16' garage door and / or large openings in a concrete wall?
Yes, if the following criteria is available for the design of a concrete lintel (beam) over the opening – concrete lintel depth minimum 16″ (400 mm) or more with no point loads. Larger openings would require an engineered design.

CMU Walls: Advantages, Disadvantages and A Better Option
Insulated concrete form blocks provide a host of advantages over traditional CMUs, including better energy efficiency, easier construction, and improved resilience.